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OCR: te to the Environmental factors that may contrib mental pathogenesis of Graves' disease. Enviro sted in Fig. factors involved in Graves' disease are effect, and 17.15. Iodine has an immune-stimulant e in areas the autoimmune thyroid diseases are r as been of iodine deficiency. Cigarette smoking , possibly associated with Graves' ophthalmopath via an effect on immune-competent cel stress Precipitation of disease by environmen but is such as bereavement has been suggested are difficult to substantiate. Infectious agen mune involved in the development of autoin r mimicry thyroid disease in animals, and molecu acteria or or non-specific immune stimulation by Induction viruses is a likely environmental trigge ollicular of class II antigen expression on thyroid nfection, cells for example, in re ...